The Epstein-Barr Virus by M. A. Epstein, B. G. Achong (auth.), M. A. Epstein M.A.,

By M. A. Epstein, B. G. Achong (auth.), M. A. Epstein M.A., M.D., Ph.D., D.Sc., F.R.C. Path., F.R.S., B. G. Achong M.B., B.Ch., B.A.O., M.D. (eds.)

The Epstein-Barr virus was once stumbled on 15 years in the past. when you consider that that point a massive physique of knowledge has been accumu­ lated in this agent which has come to imagine nice signifi­ cance in lots of various fields of organic technological know-how. therefore, the virus has very distinctive relevance in human drugs and oncology, in tumor virology, in immunology, and in mole­ cular virology, because it is the reason for infectious mononu­ cleosis and likewise the 1st human melanoma virus, etiologically relating to endemic Burkitt's lymphoma and possibly to nasopharyngeal carcinoma. furthermore, non-stop human lymphoid mobile strains initiated and maintained by way of the remodel­ ing functionality of the virus genome supply a laboratory instrument with large and ever-growing functions. Innumerable papers at the Epstein-Barr virus have ap­ peared over fresh years and stories of labor with this agent now represent a veritable flood. the current booklet presents the 1st and merely entire, authoritative over-view of all points of the virus via authors who've been the unique and significant members of their specific disciplines. a whole and updated survey of this designated and demanding agent is therefore supplied which may be of serious curiosity to specialists, lecturers, and scholars engaged in melanoma examine, virology, immunology, molecular biology, epide­ miology, and mobilephone tradition. the place issues were handled from multiple of those viewpoints, a few inevitable overlap and duplication has resulted; even supposing this has been stored to a minimal, it's been retained in a few locations as a result of optimistic usefulness.

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Blake, J. , Macrae, A. : EB virus antibody at different ages. Br. Med. J. : Isolation of herpes viruses from trigeminal ganglia of man, monkeys, and cats. J. Infect. Dis. 128, 345-348 (1973) Pope, J. , Horne, M. : Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus. Int. J. Cancer 3, 857-866 (1968) Pritchett, R. , Hayward, S. , Kieff, E. : DNA of Epstein-Barr virus. I. Comparative studies of the DNA of EBV from HR-1 and B95-8 cells.

Int. J. , Fresen, K. : Heterogeneity of Epstein-Barr virus II. Induction of early antigens (EA) by complementation. Virology 81, 138-143 (1977) 2 Morphology of the Virus and of Virus-Induced Cytopathologic Changes M. A. Epstein and B. G. Achong Department of Pathology, The Medical School, University of Bristol, University Walk, Bristol BS8 lTD (England) A. Introduction. . . 24 B. Virus Morphology . . I. Structure of the Virion 1. The Immature Particle (Nucleocapsid) 2. The Mature Enveloped Particle II.

E. : Herpesvirus saimiri. II. An experimentally induced primate disease resembling reticulum cell sarcoma. Lab. Animal Care 19, 378386 (1969) Melendez, L. , Hunt, R. , King, N. , Barahona, H. , Daniel, M. , Fraser, C. E. , Garcia, F. : Herpesvirus ateles, a new lymphoma virus of monkeys. Nature New Bio!. , Isaacs, J. : Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus. , Rose, H. , Jones, E. : Electron microscopic observations on the development of herpes simplex virus.

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