By Michel Seigneuret, Hélène Conjeaud, Hui-Tang Zhang, Xiang-Peng Kong (auth.), Fedor Berditchevski, Eric Rubinstein (eds.)
Tetraspanin proteins have lately emerged as a brand new category of modulators of varied approaches related to mobilephone floor receptors, together with phone migration and invasion, host immune responses, cell-cell fusion, and viral an infection. The e-book summarises fresh advances within the fields of biology within which the position of tetraspanins were demonstrated and likewise covers the molecular evolution of the tetraspanin superfamily and structural features of the employer of tetraspanin microdomains.
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Extra info for Tetraspanins
This latter CD tetraspanin is placed into its own family, the second largest of the four families with respect to members. This family contains the CD63 orthologs from several vertebrates and cluster of genes at chromosome location 42E in the Drosophila genome. The CD63 family of tetraspanins is highly divergent with several previously annotated vertebrate TSPAN proteins (TSPAN13, TSPAN31, TSPAN3, TSPAN6, and TSPAN7). The uroplakin family is made up of the classically named vertebrate uroplakin (UP) genes and several invertebrate tetraspanins (represented by the well-characterized Drosophila tetraspanin expansion group) as well as TSPAN32 and TSPAN12.
The four transmembrane helices of tetraspanin UPIa and UPIb are tightly packed into bundles which extend to the extracellular domains thus giving these tetraspanins an overall cylindrical shape. This is consistent with the structural model of CD81 (see Sect. 2). The single-pass UPII and UPIIIa adopt an inverted ‘L’-shape, anchored by its transmembrane helix packed against the four transmembrane helices of their specific tetraspanin partner tetraspanin, thus forming a fivehelix bundle within each subdomain.
Biochem J 420:133–154 Charrin S, Yalaoui S, Bartosch B, Cocquerel L, Franetich JF, Boucheix C, Mazier D, Rubinstein E, Silvie O (2009b) The Ig domain protein CD9P-1 down-regulates CD81 ability to support plasmodium yoelii infection. J Biol Chem 284:31572–31578 Cuff JA, Clamp ME, Siddiqui AS, Finlay M, Barton GJ (1998) JPred: a consensus secondary structure prediction server. Bioinformatics 14:892–893 Delaguillaumie A, Harriague J, Kohanna S, Bismuth G, Rubinstein E, Seigneuret M, Conjeaud H (2004) Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation.