Steroid Contraceptives and Women’s Response: Regional by Rachel Snow, Peter Hall

By Rachel Snow, Peter Hall

Pharmacokinetic variability of contraceptive steroids is a comparatively under-explored region of contraceptive study, and infrequently a typical element of debate between those that plan and carry family members making plans prone. however, various autonomous reports during the last 15 years have indicated that ladies in numerous areas of the area differ of their pharmacokinetic reaction to contraceptive steroids. The explanations of such variability aren't recognized, however it has vital results for contraceptive effectiveness. it may well additionally provide perception to the foundation of contraceptive side-effects. The impetus for this quantity was once to assemble documentation of pharmacokinetic variability of contraceptive steroids, and to discover either the prospective motives and implications of those facts. elements recognized to impact steroid pharmacokinetics, corresponding to concurrent use of particular medicines, are reviewed by way of again and Orme. different components identified to impact endogenous steroid dynamics are awarded in chapters through Bradlow, Longcope, Goldin and Snow, due to their attainable function in contraceptive steroid pharmacokinetics.

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The effects of moderate physical activity on menstrual cycle patterns in adolescence: Implications for breast cancer prevention. Br J Cancer 55:681-685. 1987. 34. Ovellette MD, MacVicar MG, Harlan G. Relationship between percent body fat and menstrual patterns in athletes and non-athletes. Nurs Res 35:330-333. 1986. 35. Belsey EM et al. Determinants of menstrual bleeding patterns among women using natural and hormonal methods of contraception. I. The influence of individual characteristics. Contraception 38:243-257.

9. 10. K. G. Ethnicfactor in health and disease. Wright. London 1989. K. et. al. Study ofNorplanf implants in Shanghai: three-year experience. Int. J. Gynecol. Obstet. 1990;33:345-357. , Luukainen, T. Liver-function tests during intake of contraceptive tablets in pre-menopausal women. Brit Med J. 1965; i:1416-7. International Committee for Contraceptive Research (lCCR). Contraception with long-acting subdermal implants: the measured and perceived effects international clinical trials. Contraception 1978;18:335-53.

G t; :... : §. , ? :l.. ""~ § Quetelet Index Age (years) Age at menarche (years) £'c Table 2. Subject characteristics by method of contraception. 10 * Range of interval lengths Table 3. )in combined oral contraceptive users. ~ ~ ~ t Regional and Individual Variation in Bleeding Patterns Associated with Steroid Contraception 45 Use of an oral contraceptive within the previous two years had a similar effect: less frequent bleeding, shorter, less variable episodes and longer intervals. Women who had used a method other than an oral pill or IUD had fewer episodes than those who had used a barrier or natural method or none.

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