By Rachel Snow, Peter Hall
Pharmacokinetic variability of contraceptive steroids is a comparatively under-explored region of contraceptive study, and infrequently a typical element of debate between those that plan and carry family members making plans prone. however, various autonomous reports during the last 15 years have indicated that ladies in numerous areas of the area differ of their pharmacokinetic reaction to contraceptive steroids. The explanations of such variability aren't recognized, however it has vital results for contraceptive effectiveness. it may well additionally provide perception to the foundation of contraceptive side-effects. The impetus for this quantity was once to assemble documentation of pharmacokinetic variability of contraceptive steroids, and to discover either the prospective motives and implications of those facts. elements recognized to impact steroid pharmacokinetics, corresponding to concurrent use of particular medicines, are reviewed by way of again and Orme. different components identified to impact endogenous steroid dynamics are awarded in chapters through Bradlow, Longcope, Goldin and Snow, due to their attainable function in contraceptive steroid pharmacokinetics.
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Extra info for Steroid Contraceptives and Women’s Response: Regional Variability in Side-Effects and Pharmacokinetics
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G t; :... : §. , ? :l.. ""~ § Quetelet Index Age (years) Age at menarche (years) £'c Table 2. Subject characteristics by method of contraception. 10 * Range of interval lengths Table 3. )in combined oral contraceptive users. ~ ~ ~ t Regional and Individual Variation in Bleeding Patterns Associated with Steroid Contraception 45 Use of an oral contraceptive within the previous two years had a similar effect: less frequent bleeding, shorter, less variable episodes and longer intervals. Women who had used a method other than an oral pill or IUD had fewer episodes than those who had used a barrier or natural method or none.