By William S. Spielman, Narayanan Parameswaran
one of several GPCRs came upon, the calcitonin relations of receptors contain of individuals that keep watch over a few physiological techniques and are curious about many pathological stipulations. for this reason, figuring out how those receptors functionality is a severe query within the box. whilst Foord and his colleagues stumbled on unmarried transmembrane protein referred to as Receptor job editing Proteins (RAMPs) may well modulate the skin expression of GPCRs of the calcitonin family members, it extensively opened the sector of receptor lifestyles cycle. thousands of reports have proven the significance of RAMPs within the lifestyles cycle of this receptor kin. Receptor biology is a swiftly increasing box and with the advances in telephone and molecular biology and in vivo options, it's very most likely that the sphere of RAMPs will explode extra and plenty of unanswered questions could be spoke back with within the following few years.
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Parameswaran N, Aiyar N, Wu H et al. Desensitization and resensitization of adrenomedullin-sensitive receptor in rat mesangial cells. Eur J Pharmacol 2000; 407(3):205-10. 8. Qi YF, Xue L, Chai SB et al. Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells—effects of receptor activity-modifying protein. Sheng Li Xue Bao 2001; 53(5):396-400. 9. Drake WM, Ajayi A, Lowe SR et al. Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: implications for the RAMP hypothesis.
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