RAMPs by William S. Spielman, Narayanan Parameswaran

By William S. Spielman, Narayanan Parameswaran

one of several GPCRs came upon, the calcitonin relations of receptors contain of individuals that keep watch over a few physiological techniques and are curious about many pathological stipulations. for this reason, figuring out how those receptors functionality is a severe query within the box. whilst Foord and his colleagues stumbled on unmarried transmembrane protein referred to as Receptor job editing Proteins (RAMPs) may well modulate the skin expression of GPCRs of the calcitonin family members, it extensively opened the sector of receptor lifestyles cycle. thousands of reports have proven the significance of RAMPs within the lifestyles cycle of this receptor kin. Receptor biology is a swiftly increasing box and with the advances in telephone and molecular biology and in vivo options, it's very most likely that the sphere of RAMPs will explode extra and plenty of unanswered questions could be spoke back with within the following few years.

Show description

Read Online or Download RAMPs PDF

Best nonfiction_9 books

Bone Marrow Pathology, Third Edition

Content material: bankruptcy 1 the conventional Bone Marrow (pages 1–50): bankruptcy 2 specific innovations acceptable to Bone Marrow analysis (pages 51–89): bankruptcy three an infection and Reactive adjustments (pages 90–140): bankruptcy four Acute Myeloid Leukaemia, the Myelodysplastic Syndromes and Histiocytic Neoplasms (pages 141–190): bankruptcy five power Myeloproliferative and Myeloproliferative/Myelodysplastic problems (pages 191–230): bankruptcy 6 Lymphoproliferative problems (pages 231–331): bankruptcy 7 a number of Myeloma and comparable issues (pages 332–359): bankruptcy eight issues of Erythropoiesis, Granulopoiesis and Thrombopoiesis (pages 360–390): bankruptcy nine Miscellaneous issues (pages 391–429): bankruptcy 10 Metastatic Tumours (pages 430–461): bankruptcy eleven ailments of Bone (pages 462–473):

Ciba Foundation Symposium 132 - Motor Areas of the Cerebral Cortex

Contains the lawsuits of a symposium held on the Ciba origin, London, February 1987. Addresses major concerns and new strategies within the research of motor components of the cerebral cortex in people and animals. studies the old improvement of the research of cortical constitution and serve as, examines anatomical connections of motor components, and surveys physiological experiences of cortical components in wide awake primates.

Self-Organizing Natural Intelligence: Issues of Knowing, Meaning, and Complexity

Self-Organizing average Intelligence brings new clinical the way to intelligence study that's at present less than the impression of principally classical nineteenth century unmarried causal conception and technique. This out-dated classical method has ended in the single-capacity g-theory, a "central processor," top-down, genetically made up our minds linguistic view of intelligence that's without delay contradicted via empirical proof of human and animal experiences of intelligence.

ICT Innovations 2012: Secure and Intelligent Systems

The current degree of the human civilization is the e-society, that is construct over the achievements acquired by way of the advance of the data and conversation applied sciences. It impacts every person, from traditional cellphone clients to designers of top of the range business items, and each human task, from taking therapy to bettering the country governing.

Extra info for RAMPs

Sample text

J Clin Invest 1993; 92(4):1781-6. 27. She nolikar S, Weinman EJ. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol 2001; 280(3):F389-95. 28. V oltz JW, Weinman EJ, Shenolikar S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene 2001; 20(44):6309-14. 29. Hall RA, Ostedgaard LS, Premont RT et al. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na /H exchanger regulatory factor family of PDZ proteins.

Parameswaran N, Aiyar N, Wu H et al. Desensitization and resensitization of adrenomedullin-sensitive receptor in rat mesangial cells. Eur J Pharmacol 2000; 407(3):205-10. 8. Qi YF, Xue L, Chai SB et al. Desensitization of adrenomedullin and calcitonin gene-related peptide receptors in vascular smooth muscle cells—effects of receptor activity-modifying protein. Sheng Li Xue Bao 2001; 53(5):396-400. 9. Drake WM, Ajayi A, Lowe SR et al. Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: implications for the RAMP hypothesis.

Nat Rev Mol Cell Biol 2004; 5(2):121-32. 19. Kurten RC. Sorting motifs in receptor trafficking. Adv Drug Deliv Rev 2003; 55(11):1405-19. 20. Hunyady L, Catt KJ, Clark AJ et al. Mechanisms and functions of AT(1) angiotensin receptor internalization. Regul Pept 2000; 91(1-3):29-44. 21. Marchese A, Raiborg C, Santini F et al. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell 2003; 5(5):709-22. 22. Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

Download PDF sample

Rated 4.45 of 5 – based on 7 votes