Protein-protein Interactions and Networks: Identification, by Peter Uetz, Björn Titz, Gerard Cagney (auth.), Anna

By Peter Uetz, Björn Titz, Gerard Cagney (auth.), Anna Panchenko, Teresa Przytycka (eds.)

The organic interactions of dwelling organisms, and protein-protein interactions particularly, are astonishingly varied and current various demanding situations to fashionable biomolecular study as a result of their complexity. research of styles and rules governing those interactions has triggered a fast improvement of computational tips on how to establish protein interplay companions and to appreciate the jobs of person parts of protein interplay networks in cellphone functions.

This ebook integrates varied techniques from bioinformatics, biochemistry, computational research and platforms biology to provide the reader a accomplished international view of the various facts on protein-protein interactions and protein interplay networks. It brings jointly the descriptions of experimental innovations and expounds on varied computational algorithms for protein community research and prediction of protein and area interactions, with every one bankruptcy containing an outline of the matter, a evaluate of equipment and algorithms, an inventory of assets and present conclusions.


• stories experimental thoughts for id of protein interactions

• Discusses protein interplay databases and strategies of integrating info from varied sources

• Describes computational how to expect protein and area interplay companions

• Explores the houses of interplay interfaces and highlights ways to version the meeting of protein complexes

• Examines the topological and dynamical homes of protein interplay networks and offers the instruments for comparative research of those networks

Written by way of prime specialists, Protein-protein Interactions and Networks offers a extensive, thorough and multidisciplinary assurance of this box. it is going to be important to researchers from academia and the bioinformatics undefined, in addition to a very good auxiliary textual content for graduate scholars learning the topic.

Show description

Read or Download Protein-protein Interactions and Networks: Identification, Computer Analysis, and Prediction PDF

Similar nonfiction_9 books

Bone Marrow Pathology, Third Edition

Content material: bankruptcy 1 the traditional Bone Marrow (pages 1–50): bankruptcy 2 targeted concepts appropriate to Bone Marrow analysis (pages 51–89): bankruptcy three an infection and Reactive alterations (pages 90–140): bankruptcy four Acute Myeloid Leukaemia, the Myelodysplastic Syndromes and Histiocytic Neoplasms (pages 141–190): bankruptcy five power Myeloproliferative and Myeloproliferative/Myelodysplastic issues (pages 191–230): bankruptcy 6 Lymphoproliferative issues (pages 231–331): bankruptcy 7 a number of Myeloma and comparable issues (pages 332–359): bankruptcy eight problems of Erythropoiesis, Granulopoiesis and Thrombopoiesis (pages 360–390): bankruptcy nine Miscellaneous issues (pages 391–429): bankruptcy 10 Metastatic Tumours (pages 430–461): bankruptcy eleven illnesses of Bone (pages 462–473):

Ciba Foundation Symposium 132 - Motor Areas of the Cerebral Cortex

Contains the complaints of a symposium held on the Ciba beginning, London, February 1987. Addresses major matters and new innovations within the learn of motor parts of the cerebral cortex in people and animals. reports the ancient improvement of the examine of cortical constitution and serve as, examines anatomical connections of motor parts, and surveys physiological experiences of cortical components in wakeful primates.

Self-Organizing Natural Intelligence: Issues of Knowing, Meaning, and Complexity

Self-Organizing traditional Intelligence brings new clinical how to intelligence examine that's at present below the impact of mostly classical nineteenth century unmarried causal thought and technique. This out-dated classical method has ended in the single-capacity g-theory, a "central processor," top-down, genetically decided linguistic view of intelligence that's without delay contradicted by way of empirical evidence of human and animal reviews of intelligence.

ICT Innovations 2012: Secure and Intelligent Systems

The current level of the human civilization is the e-society, that's construct over the achievements received by way of the improvement of the data and conversation applied sciences. It impacts every person, from traditional cellphone clients to designers of top quality commercial items, and each human job, from taking treatment to bettering the nation governing.

Additional resources for Protein-protein Interactions and Networks: Identification, Computer Analysis, and Prediction

Sample text

U. S. A. 95(20): 11810–11815. Ong, S. , Kristensen, D. , Pandey, A. and Mann, M. (2002). Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteomics 1(5): 376–386. Patil, A. and Nakamura, H. (2005). Filtering high-throughput protein-protein interaction data using a combination of genomic features. BMC Bioinformatics 6: 100. Pawson, T. and Nash, P. (2003). Assembly of cell regulatory systems through protein interaction domains.

Fields, S. and Rothberg, J. M. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770): 623–627. Uetz, P. and Stagljar, I. (2006). The interactome of human EGF/ErbB receptors. Mol. Syst. Biol. 2: 2006 0006. Vojtek, A. , Hollenberg, S. M. and Cooper, J. A. (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74(1): 205–214. Vollert, C. S. and Uetz, P. (2004). The phox homology (PX) domain protein interaction network in yeast.

2006). A novel conserved assembly factor of the bacterial flagellum. J. Bacteriol. 188: 7700–7706. , Schlesner, M. and Uetz, P. (2004). What do we learn from high-throughput protein interaction data? Expert Rev. Proteomics 1(1): 111–121. , Dong, Y. , Rajagopala, S. , Fossum, E. and Haas, J. (2006). Herpesviral protein networks and their interaction with the human proteome. Science 311(5758): 239–242. , James, D. and Zeller, R. (1996). Molecular interaction between limb deformity proteins (formins) and Src family kinases.

Download PDF sample

Rated 4.64 of 5 – based on 38 votes