Progress in Drug Research / Fortschritte der by M. W. Anders, A. L. Bassett, A. L. Wit, L. Bolis, R. B.

By M. W. Anders, A. L. Bassett, A. L. Wit, L. Bolis, R. B. Burrows, J. J. Hlavka, J. H. Boothe, P. J. Islip, J. A. Montgomery, R. F. Struck, J. S. Bindra, R. Bindra, F. Kratz (auth.), Dr. Ernst Jucker (eds.)

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Extra info for Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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For example, if the slowly propagating action potential lowers membrane potential of unexcited regions towards the threshold potential too slowly then the threshold potential may be decreased (become less negative) because of a reduction in the availability of sodium carrier [41]. The propagating action potential in turn becomes a poorer stimulus to unexcited tissue since more depolarization is needed to reach the altered threshold potential and initiate a new action potential. This new action potential will be elicited at a lower transmembrane potential and will have still a lower rate of rise and amplitude.

Phentolamine . . . . . . Classification of Antiarrhythmic Drugs Conclusion. References. . . . . . 1) Supported in part by NHLI Grant 12738. 2) Recipient Career Development Award, NHLI K4-HE-42500. 3) Senior Investigator of the New York Heart Association. 3 Arzneimi ttel 17 34 34 36 38 39 40 42 44 44 45 47 47 47 50 51 51 54 54 34 A. L. Bassett 1. Introduction In this review, we are concerned with the most recent advances in single cell cardiac electrophysiology and pharmacology.

More recently, Singh and Vaughan Williams have described two additional classes. ·Class 3 contains agents which have an antiarrhythmic action resulting from their effects to delay repolarization and thus prolong the cardiac action potential [156, 157]. Class 4 has been suggested in order to characterize the action of Verapamil which apparently does not act in a manner similar to the drugs of the other three classes [158]. Singh and Vaughan Williams suggest that Verapamil acts by interfering with or altering the changes in calcium conductance that occur during the action potential [158].

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