Peritoneal Carcinomatosis: A Multidisciplinary Approach by Steven E. Mutsaers, Sylwia Wilkosz (auth.), Wim P. Ceelen MD

By Steven E. Mutsaers, Sylwia Wilkosz (auth.), Wim P. Ceelen MD (eds.)

Recent advancements in local and systemic anticancer remedies have more advantageous the awful outlook of sufferers with peritoneal carcinomatosis (PC) from ovarian or gastrointestinal beginning, resulting in a renewed curiosity in either the underlying mechanisms on the foundation of laptop and a number of the healing options.

This is the 1st quantity to supply a multidisciplinary method of peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, nearby and systemic cytotoxic remedy, and surgical strategies. Peritoneal Carcinomatosis: A Multidisciplinary Approach might be of curiosity for scientific, surgical and gynecological oncologists confronted with the complexities of selection making in sufferers being affected by workstation, in addition to for uncomplicated and translational scientists lively within the box of locoregional melanoma unfold. a number of illustrations reduction the reader all through within the many points of this disease.

"Peritoneal Carcinomatosis is still a hard final result of melanoma linked to major morbidity. This usually devastating situation merits from a multidisciplinary method of sufferer care. this article presents a close assessment of the pathologic entities, biologic concerns and healing techniques as considered by means of specialists within the field."

Steven T. Rosen, M.D.

Series Editor

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Burleson KM, Hansen LK, Skubitz AP (2004) Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers. Clin Exp Metastasis 21(8):685-697 83. Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T (2003) Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells. J Biol Chem 278(29):26793-26802 84.

Indeed, Kayastha et al. 10 SE Mutsaers, S Wilkosz [73] found that expression of the standard form of CD44 (CD44S) was significantly associated with poorer disease free survival of ovarian cancer patients. Blocking interaction of CD44 and hyaluronan using antisense CD44 cDNA [74], monoclonal antibodies that block the hyaluronan-binding site of CD44 [65,67,72], intact hyaluronan and hyaluronan oligomers [64,67], reduced cell adhesion and inhibited cell migration. Although mesothelial cells either directly or indirectly appear to promote tumour dissemination and growth, intact hyaluronan inhibits the adhesion of tumour cells to mesothelium [67].

Nephrol Dial Transplant 11(9):1803-1809 Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J (2001) Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J Am Soc Nephrol 12(10):2029-2039 Ma C, Tarnuzzer RW, Chegini N (1999) Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in mesothelial cells and their regulation by transforming growth factor-beta1. Wound Repair Regen 7(6):477-485 Yung S, Thomas GJ, Stylianou E, Williams JD, Coles GA, Davies M (1995) Source of peritoneal proteoglycans.

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