By Johann Caspar Rüegg (auth.), Professor Dr. Johann Caspar Rüegg (eds.)
Protein-protein interactions are inquisitive about muscle contraction and sign transduction. This e-book describes how artificial peptides can be used, very like antibodies, either as particular inhibitors and as molecular probes to discover the cognitive interfaces among interacting proteins and their useful importance. this gives the chance of very selective intervention in mobile mechanisms. those well timed contributions through numerous specialists will attract the researchers in muscle body structure, cardiovascular pharmacology and mobile biology who're attracted to this new approach.
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Extra resources for Peptides as Probes in Muscle Research
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8 ~M were used. complex. peptides As shown in Table I, the dissociation constants of (1) and (2) had almost the same values. The dissociation constants of peptides (3) and (4) also had values similar to each other. The N-terminal extra tetrapeptide segment of peptides (1) and (3), Val-Leu-Glu-Gly, does not appear to contribute significantly to the binding with F-actin. Therefore, the heptapeptide, peptide (2), is critical for this binding. In this heptapeptide, the N-terminal Ile-Arg-Ile segment appears to be more important for the binding with Factin than the C-terminal Cys-Arg-Lys-Gly segment since the affinity for F-actin of tripeptide (4) was about 10 times higher than that of tetrapeptide (5).
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