Oxidative Stress by Helmut Sies (Eds.)

By Helmut Sies (Eds.)

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J. Radiat. Biol. 35, 449-458. , von Sonntag, C. and Witzel, H. (1981). Int. J. Radiat. Biol. 39, 185- 193. Howard, J. A. (1973). In: "Free Radicals" (J. K. ), Vol 2, pp. 3-62. Wiley, New York. Howard, J. A. and Ingold, K. U. (1968). J. Am. Chem. Soc. 90, 1056-1058. Howard, Flanders, P. (1960). Nature (London) 186, 485-487. , Levin, J. and Theriot, L. (1963). Radiat. Res. 18, 593-606. Hutchinson, F. (1961). Radiat. Res. 14, 721-731. Hutchinson, F. (1966). Cancer Res. 26, 2045-2052. , Schuchmann, M.

Ward, J. F , Jones, E. I. and Blakely, W. F. (1984). Cancer Res. 44, 5 9 - 6 3 . Washino, K. and Schnabel, W. (1982). Int. J. Radiat. Biol. 41, 271-282. Weber, K. J. and Kiefer, J. (1983). Proc. 7th Int. Congr. Radiat. , Amsterdam. Vol. B, 3 - 32. , and Sies, H. (1983). Eur. J. Biochem. 137, 2 9 - 3 6 . West, G. , West, I. , and Ward, J. F. (1982a). Radiat. Res. 90, 595-608. West, G. , West, I. , and Ward, J. F. (1982b). Int. J. Radiat. Biol. 42, 481-490. Willson, R. L. (1970). Int. J. Radiat. Biol.

RADIOLYSIS OF DNA 31 presence of four different bases, many more different reactions are possible than in poly(U). Henner et al (1982, 1983) have shown that the —OCH COOH group is formed as an end group in irradiated DNA, which is expected if the mechanism proposed for poly(U) is operative in DNA. Two different kinds of double strand breaks (dsb) have been postulated, a frank break and breaks at labile sites after postirradiation incubation in neutral solution (Ward, 1981). Lafleur et al (1979) observed an alkali-labile site in dsDNA which is identical with the damage produced by postirradiation heat treatment.

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