Molecular Mechanisms in Spermatogenesis by Rex A. Hess, Luiz Renato de Franca (auth.), C. Yan Cheng PhD

By Rex A. Hess, Luiz Renato de Franca (auth.), C. Yan Cheng PhD (eds.)

In the prior thirty years, major advances were made within the box of reproductive biology in unlocking the molecular and biochemical occasions that keep watch over spermatogenesis within the mammalian testis. It used to be attainable as a result of the extraordinary breakthroughs in molecular biology, phone biology, immunology, and biochemistry.

In this e-book entitled, Molecular Mechanisms in Spermatogenesis, a suite of chapters has been integrated written through colleagues at the most modern improvement within the box utilizing genomic and proteomic methods to check spermatogenesis, in addition to assorted mechanisms and/or molecules together with environmental toxicants and transcription components that control and/or have an effect on spermatogenesis. The booklet starts with a bankruptcy that offers the elemental proposal of mobile legislation of spermatogenesis. a couple of chapters also are devoted to the various most up-to-date findings at the Sertoli telephone cytoskeleton and different molecules (e.g., proteases, adhesion proteins) that keep an eye on spermatogenesis. those chapters include thought-provoking discussions and ideas which can be welcomed via investigators within the box. it's seen that a lot of those recommendations can be up to date and a few could be amended within the years yet to come. although, they are going to function a consultant and the root for research by means of scientists within the field.

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Extra info for Molecular Mechanisms in Spermatogenesis

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Biol Reprod 1990; 42(4):603-612. 93. Chung SS, Sung W, Wang X et al. Retinoic acid receptor alpha is required for synchronization of spermatogenic cycles and its absence results in progressive breakdown of the spermatogenic process. Dev Dyn 2004; 230(4):754-766. 94. Weber JE, Russell LD, Wong V et al. Three-dimensional reconstruction of a rat stage V Sertoli cell: II. Morphometry of Sertoli-Sertoli and Sertoli-germ-cell relationships. Am J Anat 1983; 167(2):163-179. 95. Brinster RL, Avarbock MR.

These studies highlighted an unexpected diversity of mRNA species and led to two major conclusions: (1) The RNA content of spermatozoa is representative of spermatogenesis and can therefore be used to assess sperm quality and/or to explore certain cases of male sterility and (2) the spermatozoon may deliver more than just its DNA to the oocyte. It may also concern coding and noncoding transcripts playing an important role in early zygote development. However, it remains difficult to discriminate between the thousands of sperm transcripts that will be translated into “true spermatozoon proteins” and residual transcripts used at earlier steps of spermatogenesis.

Schulz RW, Menting S, Bogerd J et al. Sertoli cell proliferation in the adult testis—Evidence from two fish species belonging to different orders. Biol Reprod 2005; 73(5):891-898. 80. McCoard SA, Wise TH, Lunstra DD et al. Stereological evaluation of Sertoli cell ontogeny during fetal and neonatal life in two diverse breeds of swine. J Endocrinol 2003; 178(3):395-403. 81. Neves ES, Chiarini-Garcia H, Franca LR. Comparative testis morphometry and seminiferous epithelium cycle length in donkeys and mules.

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