By H. Michelle Grandin (Editor), Marcus Textor (Editor), George M. Whitesides (Foreword by)
A finished assessment of shrewdpermanent and responsive surfaces in biotechnology and their applications
A wave of contemporary advances in mobilephone biology, biophysics, chemistry, and fabrics technological know-how has enabled the advance of a brand new new release of clever biomaterials. clever Surfaces in Biotechnology: medical and Engineering innovations, permitting applied sciences, and Translation to Bio-Oriented functions presents readers with a finished evaluation of floor transformations and their functions, together with assurance of the physico-chemical houses, characterization equipment, shrewdpermanent coating applied sciences, and demonstration of functionality in vitro and in vivo.
The first a part of the e-book covers functions within the fields of biosensing and biodiagnostics, whereas the second one half focuses extra on coatings for scientific units, drug supply, and adapted cell-surface interactions. The publication explores clever floor purposes similar to tissue engineering, drug concentrating on and supply, wound therapeutic and anti-infection innovations, biosensors, nanopatterning, and bioinspired layout of novel responsive fabrics and multifunctional surfaces.
Designed to help scientists and engineers in realizing the speedily constructing box of biofunctional surfaces, clever Surfaces in Biotechnology is an edited quantity with each one bankruptcy written through a revered specialist and that includes examples taken from the main cutting-edge advancements within the discipline.
Cover photo: layout proposal for a diagnostic microfluidic procedure in response to responsive polymer- and antibody-conjugated nanobeads (see bankruptcy 2 of this booklet, determine 2.5; reproduced by means of permission from the Royal Society of Chemistry).
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Additional info for Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications
Y. Review—hydrogels as smart biomaterials. Polymer International 56, 1078–1098 (2007). 44. B. Methods for synthesis of hydrogel networks: a review. Journal of Macromolecular Science—Reviews in Macromolecular Chemistry and Physics C36, 405–430 (1996). REFERENCES 25 45. , & Ruhe, J. Polymer Brushes: Synthesis, Characterization, Applications. Weinheim, Germany: Wiley (2004). 46. S. Polymer brushes via surfaceinitiated polymerizations. Chemical Society Reviews 33, 14–22 (2004). 47. Minko, S. Responsive polymer brushes.
Using sequential deposition of oppositely charged PELs, multilayers with a desired structure, chemical composition, and thickness can be assembled on the substrate. 49,50 Due to the short- and long-range interactions between the layers in the polymer ﬁlm assembly, stimuli that perturb the equilibrium of these interactions will cause volumetric expansion or contraction of the layers. Similar to other responsive polymer coatings, the change in the layer conformation upon exposure to an analyte or stimulus can be exploited to transduce a binding event or change in the solvent environment.
Thus, SRP coatings 20 POLYMERS AS INTELLIGENT COATINGS FOR BIOSENSORS with ampliﬁcation potential, for example, through reaction cascades, need to be developed to further improve the performance of SRP coatings. 2 Selectivity SRP coatings can be engineered to selectively detect a wide range of analytes. This selectivity is typically obtained by incorporating analyte-speciﬁc recognition elements into the SRP coating. However, despite a range of available strategies to impart selectivity, nonspeciﬁc interactions with SRPs can limit signal-to-noise ratios.