Immunobiology of Bacterial CpG-DNA by A. M. Krieg, G. Hartmann, A.-K. Yi (auth.), Professor Dr.

By A. M. Krieg, G. Hartmann, A.-K. Yi (auth.), Professor Dr. Hermann Wagner Ph.D. (eds.)

Bacterial CpG-DNA sequences not just serve for genetic info yet act as "danger" sign to alert immune cells equivalent to macrophages and dendritic cells. CpG-DNA at once reasons activation of those contributors of the innate immune method yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to advertise protecting Th1 polarized T telephone immune responses. This publication is the 1st accomplished evaluation of the knowledge rising during this field.

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J Immunol 157:5394-5402 Yi A-K, Krieg AM (1998) CpG DNA rescue from anti-IgM induced WEHI-23I B lymphoma apoptosis via modulation of IkBct and IkB/3 and sustained activation of nuclear factor-k BjcRel. J Immunol 160:1240-1245 Yi A-K, Tuetken R, Redford T, Waldschmidt M, Kirsch J, Krieg AM (1998) CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 160:4755-4761 Zimmermann S, Egeter 0, Hausmann S, Lipford GB, Rocken M, Wagner H, Heeg K (1998) CpG oligodeoxynucleotides trigger protective and curative Th I response in lethal murine leishmaniasis.

Blood 88:1788-1795 Zhao Q, Temsamani J, Zhou R-Z, Agrawal S (1997) Pattern and Kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. Antisense and Nucleic Acid Drug Develop 7:495-502 Zimmerman S, Egeter 0, Hausmann S, Lipford GB, Rocken M, Wagner H, Geeg K (1998) Cutting Edge: CpG oligodeoxynucleotides trigger protective and curative Thl responses in lethal murine leishmaniasis. J Immunol 160:3627-3630 Oligodeoxyribonucleotides with 5'-ACGT-3' or 5'-TCGA-3' Sequence Induce Production of Interferons S.

2 or carbonyl-iron uptake, suggesting that the effector cells are NK cells (SHIMADA 1986; YAMAMOTO 1988). Ip injection with DNase-digest of BCG-DNA did not bring such NK activation. Intra-dermal (id) injection of BCG-DNA induced in situ infiltration of mononuclear cells (most of which were asialo-GM1-positive) and lasted for a week. 2 but negative for Mac-I, la, mu-chain, Lyt-1, Lyt-2, L3T4, and Fc receptor II. They contained neither peroxidase nor nonspecific esterase, suggesting that the cells were NK.

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