Experimental Epilepsy [Prog. in Brain Research Vol 19] by A. Kreindler

By A. Kreindler

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Moreover the focus in the median centre does not propagate, which would be in accord with certain peculiarities in the organization of cerebral epileptic aclivity, as also pointed out by Kreindler, Voiculescu et al. (1956b). , 1964). , 1960). About 2 to 4 min elapse between the application of penicillin and the appearance of the first epileptic discharges. These first discharges are of low voltage and become simple mono- or diphasic spikes. Later, both their amplitude and their complexity increase, and varied spikewave complexes are formed.

18). Fig. 18. Spontaneous unit activity in epileptic cortex. Note long ‘tonic’ trains of high-frequency unit discharge with occasional responses and higher frequency bursts. Time mark, 50 msec. ) 42 THE EXP E RIM ENTAL E P I L E P T O G E N I C FOC U S Sawa et al. (1963) studied the intracellular potentials during the whole process of epileptic seizures induced electrically in the cerebral cortex and the hippocampus by single shock and repetitive electrical stimulation. Most cortical and hippocampal neurons showed a depolarizing wave followed by a hyperpolarizing wave in response to a single pulse at the surface.

Ralston (1958) showed that the after-discharge that follows a strychnine spike is rapid, rhythmic, of relatively low voltage, and comes after the slow terminal wave of a spike complex actually representing an embryo seizure. The more widely spread paroxysmal activity arises from this after-discharge rather than from fusion of the spike complexes between the seizures. Therefore, the seizure does not arise from a progressive increase in the frequency of the spikes between the seizures, but from interpolation of a new form of electrical activity - the after-discharge.

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