Erectile Dysfunction - A Medical Dictionary, Bibliography, by Icon Health Publications

By Icon Health Publications

It is a 3-in-1 reference ebook. It supplies a whole scientific dictionary masking 1000s of phrases and expressions in relation to erectile disorder. It additionally provides wide lists of bibliographic citations. ultimately, it presents info to clients on the way to replace their wisdom utilizing numerous net assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with study devoted to erectile disorder. in the event that your time is effective, this ebook is for you. First, you won't waste time looking the web whereas lacking loads of suitable info. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing enormous quantities of websites.

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Extra info for Erectile Dysfunction - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Example text

Many selective PDE inhibitors have been studied as therapeutic agents such as cardiotonic agents, vasodilators, antiasthma, atithrombic compounds, smooth muscle relaxants and antidepressants. For example, VIAGRA, an inhibitor of PDE5, is a prescription drug for erectile dysfunction of male patients. This proposal aims at characterization of substrate specificity and inhibitor selectivity by the approach of crystallography. The specific aims are to determine crystal structures of PDEs and their complexes with inhibitors including (1) the catalytic domain of PDE4B, (2) the catalytic domain of PDE4B complexed with the inhibitors rolipram and iodonated cAMP, (3) full length PDE4D and its complexes with the inhibitors rolipram and denbufylline and (4) the catalytic domain of PDE3 and its complex with cilostamide.

These two features of PDE have attracted great attention from pharmaceutical companies in the past decade. Many selective PDE inhibitors have been studied as therapeutic agents such as cardiotonic agents, vasodilators, antiasthma, atithrombic compounds, smooth muscle relaxants and antidepressants. For example, VIAGRA, an inhibitor of PDE5, is a prescription drug for erectile dysfunction of male patients. This proposal aims at characterization of substrate specificity and inhibitor selectivity by the approach of crystallography.

This article reviews the newer pharmacologic alternatives for ED. The underlying cause of ED is usually a chronic medical illness or a side effect of certain drugs. Less commonly, the problem is psychogenic. Even after optimal treatment of common medical disorders such as diabetes mellitus and hypertension, ED may persist. The authors note that drug therapy, such as the intracavernosal (injected into the cavernosa of the penis) or transurethral administration of alprostadil (Caverject or MUSE) or the use of the new oral medication sildenafil (Viagra), may offer patients substantial benefit.

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