DNA Damage and Repair: Advances from Phage to Humans by Carol Bernstein, Harris Bernstein (auth.), Jac A. Nickoloff,

By Carol Bernstein, Harris Bernstein (auth.), Jac A. Nickoloff, Merl F. Hoekstra (eds.)

In fresh years it has turn into more and more obvious that DNA fix procedures play key roles in retaining genome integrity, the place the failure of fix platforms is at once chargeable for many, if no longer nearly all of, cancers. In DNA harm and service, Vol. III: Advances from Phage to people, Jac A. Nickoloff and Merl F. Hoekstra replace and extend their past acclaimed volumes (Vol. I: DNA fix in Prokaryotes and reduce Eukaryotes and Vol. II: DNA fix in better Eukaryotes) with state-of-the-art reports by way of prime experts of basic experimental findings approximately DNA fix procedures in melanoma biology. The reports disguise quite a lot of issues from viruses and prokaryotes to raised eukaryotes, and comprise a number of new themes, between them the position of recombination in replication of broken DNA, X-ray crystallographic research of DNA fix protein constructions, DNA fix proteins and teleomere functionality, and the jobs of BRCA1 and BRCA2 in DNA fix. The individuals make each attempt to combine the fundamental experimental details with scientific features of melanoma biology as they relate to DNA repair.
Authoritative and up to date, DNA harm and service, Vol. III: Advances from Phage to people surveys the speedily relocating examine in DNA harm and service, supplying wide built-in assurance that may support researchers comprehend the real sensible relationships between varied DNA fix pathways, in addition to the relationships between DNA fix pathways, melanoma etiology, and melanoma therapies.

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Mol. Microbiol. 20: 1145-1154. 55. Palit, B. , G. Das, and J. Das. 1983. Repair ofultraviolet light-induced DNA damage in cholera bacteriophage. J. Gen. Virol. 64: 1749-1755. 56. Purmal, A. , L. E. Rabow, G. W. Lampman, R. P. Cunningham, and Y. W. Kow. 1996. A common mechanism of action for the N-glycosylase activity of DNA N-glycosylase/AP lyases from E. coli and T4. Mutat. Res. 364: 193-207. DNA Repair in Bacteriophage 19 57. Reha-Krantz, L. , R. L. Nonay, R. S. Day, and S. H. Wilson. 1996. Replication of 06- methylguanine-containing DNA by repair and replicative DNA polymerases.

Genetic analysis of UV mutagenesis of the Eseheriehia eoli glyU gene. Mol. Gen. Genet. 207: 1-8. 13. Clark, A. J. 1991. ree genes and homologous recombination on Eseheriehia eoli. Bioehirnie 73: 523-632. 14. Clark, A. , and S. 1. Sandler. 1994. Homologous genetic recombination. Crit. Rev. Mierobiol. 20: 125-142. 38 Sandler 15. , and A. Laban. 1983. Plasmidic recombination in Escherichia coU K-12: the role of recF gene function. Mol. Gen. Genet. 189: 471-474. 16. , C. Carswell-Crumpton, and P. C.

In summary, it appears that the ReeFOR proteins are eapable of a variety of aetivities in vitro either singly or in eombination that eould be useful in recombination. Whether any of these aetivities is used by these pro teins in vivo remains to be proven. 5. A MODEL FOR THE ROLE OF RecFOR IN THE CELL It is arguable that the main funetion of reeombination is to help restart stalled replieation forks (17,18,36,99). , RecA, ReeFOR), and then restarting of the replieation maehinery. Severalobservations mentioned previously are eonsistent with ReeFOR having an important role in the repair of eollapsed and/or stalled replieation forks by reeombinational DNA repair.

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