Cytoskeleton and Human Disease by Vera Dugina, Richard Arnoldi, Paul A. Janmey, Christine

By Vera Dugina, Richard Arnoldi, Paul A. Janmey, Christine Chaponnier (auth.), Maria Kavallaris (eds.)

The cytoskeleton is constituted of a number of really good proteins, and is a dynamic constitution that's eager about the vast majority of key mobile occasions. there's expanding curiosity within the function of the cytoskeleton in human disorder. This quantity brings jointly human illness states the place cytoskeletal disruptions are riding ailment. Our rising realizing of the molecular and mobile occasions that force cytoskeletal mediated illnesses together with melanoma, middle disorder, myopathies and epidermis problems, also are aiding form certain healing techniques to treating those diseases.

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Tzima E, Trotter PJ, Orchard MA, Walker JH (2000) Annexin V relocates to the platelet cytoskeleton upon activation and binds to a specific isoform of actin. Eur J Biochem 267:4720– 4730 64. Gallant C, Appel S, Graceffa P, Leavis PC, Lin JJ, Gunning PW, Schevzov G, Chaponnier C, Degnore J, Lehman W, Morgan KG (2011) Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells. Am J Physiol Cell Physiol 300(6):1356–1365 65. Storti RV, Coen DM, Rich A (1976) Tissue-specific forms of actin in the developing chick.

Kim HR, Gallant C, Leavis PC, Gunst SJ, Morgan KG (2008) Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent. Am J Physiol Cell Physiol. 295:C768–778 Chapter 2 Microtubules Pavel Dráber and Eduarda Dráberová Abstract Microtubules, assembled from heterodimers of α- and β-tubulin, are hollow tubes of about 25 nm in diameter, participating in essential cellular functions such as maintenance of cell shape, cell division, cell motility, and ordered intracellular transport.

The availability of such an antibody has motivated consideration of α-SMA as a marker of differentiation, not only in the typical vascular SMCs during development, during atheromatous process, and in various pathological situations, but interestingly also in a large number of other cells such as myofibroblasts, myoepithelial cells, myoid cells, and pericytes [109]. These cells could be classified as SM-like cells because of the organization of a contractile apparatus detected at the EM level and the expression of α-SMA.

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