By International Agency for Research on Cancer
This ninety-first quantity of IARC Monographs includes reviews of the carcinogenic probability to people of mixed estrogen-progestogen contraceptives and mixed estrogen-protestogen menopausal treatment. The hormonal medicines reviewed during this quantity contain co-administration of an estrogen and a progestogen. reviews that didn't supply details at the use of mixed estrogen-progestogen brokers aren't reviewed. it's going to even be famous that this quantity stories simply reports which are publicly on hand and hence doesn't contain pharmaceutical try out effects that aren't within the public area.
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Extra info for Combined Estrogen-Progestogen Contraceptives and Combined Estrogen-Progestogen Menopausal Therapy (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans : Volume 91)
Recent trends suggest that overall use has continued to increase slowly in some regions, while it has remained constant in others. The demographic and social characteristics of combined hormonal contraception users are known to differ from those of non-users of these drugs. 2 Historical overview Researchers in the late nineteenth century noted that follicular development and ovulation were suppressed during pregnancy and that extracts of the corpus luteum inhibited ovulation in laboratory animals.
18. The available data are interpreted critically by phylogenetic group according to the end-points detected, which may include DNA damage, gene mutation, sister chromatid exchange, micronucleus formation, chromosomal aberrations, aneuploidy and cell transformation. The concentrations employed are given, and mention is made of whether use of an exogenous metabolic system in vitro affected the test result. These data are given as listings of test systems, data and references. , 1987) using software for personal computers that are Microsoft Windows® compatible.
The form of the dose–response relationship can vary widely, depending on the particular agent under study and the target organ. Both DNA damage and increased cell division are important aspects of carcinogenesis, and cell proliferation is a strong determinant of dose–response relationships for some carcinogens (Cohen & Ellwein, 1990). Since many chemicals require metabolic activation before being converted into their reactive intermediates, both metabolic and pharmacokinetic aspects are important in determining the dose–response pattern.