Methods and purposes of records in medical Trials, quantity 1: suggestions, ideas, Trials, and Designs effectively upholds the ambitions of the Wiley Encyclopedia of scientific Trials through combining either previously-published and newly built contributions written by way of over a hundred prime lecturers, researchers, and practitioners in a complete, approachable layout. the result's a succinct reference that unveils smooth, state-of-the-art ways to buying and knowing information during the quite a few levels of medical trial layout and research.
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Chapter 1 points of the Histochemistry of the Adrenal Cortex (pages 1–17): G. H. Bourne
Chapter 2 a few Observations at the challenge of Cortical Zoning (pages 18–30): J. M. Yoffey
Chapter three Mitotic job within the Adrenal Cortex Studied within the Rat (pages 31–41): D. B. Cater and M. P. Stack?Dunne
Chapter four Cellular?Vascular Relationships within the Adrenal Cortex, as Studied within the Rat (pages 42–51): J. D. Lever
Chapter five reviews at the Anatomy of the Human Adrenal Cortex in a number of practical States (pages 52–69): Benjamin H. Landing
Chapter 6 The response of the Adrenal Cortex in stipulations of tension (pages 70–91): T. Symington, A. R. Currie, R. C. Curran and J. N. Davidson
Chapter 7 The Adrenal and Famine (pages 92–96): E. Uehlinger
Chapter eight The Synthesis of Corticosteroids through the Human Adrenal Cortexs (pages 97–111): G. Pincus and E. B. Romanoff
Chapter nine Adrenocortical Steroids in people: Metabolism and Generalizations (pages 112–140): Ralph I. Dorfman
Chapter 10 Adrenocortical functionality and Plasma 17?Ketosteroids in guy (pages 141–156): Claude Migeon
Chapter eleven Gradient Elution Chromatography of Corticosteroids in Human Blood (pages 157–169): C. J. O. R. Morris and D. C. Williams
Chapter 12 The Biosynthesis of Aldosterone (Electrocortin) within the Adrenal (pages 170–189): A. Wettstein, F. W. Kahnt and R. Neher
Chapter thirteen Excretion of Sodium?Retaining elements in people (pages 190–203): E. H. Venning, Bertha Singer, A. Carballeira, I. Dyrenfurth, J. C. Beck and C. P. Giroud
Chapter 14 the prospective position of Electrocortin in basic Human Metabolism (pages 204–227): Sylvia A. Simpson and J. F. Tait
Chapter 15 organic stories with Aldosterone (Electrocortin) (pages 228–240): Robert Gaunt
Chapter sixteen Medullary?Cortical Relationships within the Adrenal (pages 241–253): Marthe Vogt
Chapter 17 The influence of Epinephrine at the Metabolism of 17?Hydroxycorticosteroids within the Human (pages 254–267): F. H. Tyler, C. Migeon and H. Castle
Chapter 18 courting among Cortical Hormones and the Catechol Amine Output in Urine (pages 268–276): U. S. von Euler
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Extra resources for Ciba Foundation Symposium - The Human Adrenal Cortex (Book I of Colloquia on Endocrinology), Volume VIII
31, 376. LEVER,J. , CATER, D. , and STACK-DUNNE, M. P. (1953). , 172,33. MOOG,F. (1946). Bwl. , 21, 41. ROBINSON, F. , and YOFFEY,J. M. (1950). J . Anat. , 84,32. ROCHE, J. (1950). In “The Enzymes”, ed. Sumner, J. , Vol. I. Part I, p. 473. New York: Academic Press. , SAYERS, M. A,, LIANG,T. , and LONG,C. N. H. (1945). Endocrinology, 38, 1. SELIGMAN, A. , and ASHBEL,R. (1951). Cancer, 4,579. VOGT,M. (1948). J. , 107, 239. YOFFEY,J. M. (1953). “The Suprarenal Cortex”, ed. Yoffey, p. 31. London: Butterworth.
4). In the second experiment rats hypophysectomized ten days previously were used in MITOTICACTIVITY IN RATADRENAL CORTEX 39 the hope that they might respond more actively. This experiment suggests a response at six hours. In a third experiment, using rats hypophysectomized three weeks previously, an initial dose of 1 mg. was followed by 0 . 5 mg. every eight hours. The results shown in Fig. 4 suggest eight hours as the maximal response (cf. experiments 1 and 2). The results at twelve, sixteen and twenty-four hours were variable.
The adrenals we get are anything from six to forty-eight hours after death, and a mitotic study is quite useless. VOGT:You assumed that in animals the zona reticularis is more quiescent than the other zones. Is there any indication that this is not so in man? YOFFEY:One of the really striking indications is the clinical and pathological study of Dr. Blackman. He showed that in adrenal virilism there is usually quite marked hypertrophy of the reticularis. And certainly in prolonged ACTH stimulation you get hypertrophy of the reticularis, even in animals.