Ciba Foundation Symposium 94 - Malaria and the Red Cell

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Chapter 1 advent (pages 1–2): D.J. Weatherall
Chapter 2 Erythrocyte Membrane constitution and serve as (pages 3–23): M. J. A. Tanner
Chapter three Maturation of the Intracellular Parasite and Antigenicity (pages 24–44): ok. N. Brown, D. B. Boyle and C. I. Newbold
Chapter four Structural Alteration of the Erythrocyte Membrane in the course of Malarial Parasite Invasion and Intraerythrocytic improvement (pages 45–63): Masamichi Aikawa and Louis H. Miller
Chapter five shipping of Ions in Erythrocytes contaminated through Plasmodia (pages 64–73): Kazuyuki Tanabe, Ross B. Mikkelsen and Donald F. H. Wallach
Chapter 6 The Anaemia of Plasmodium falciparum Malaria (pages 74–97): D. J. Weatherall, S. Abdalla and M. J. Pippard
Chapter 7 The Spleen in Malaria (pages 98–116): David J. Wyler
Chapter eight impact of the Spleen at the Expression of floor Antigens on Parasitized Erythrocytes (pages 117–136): John W. Barnwell, Russell J. Howard and Louis H. Miller
Chapter nine protecting Immunity to Malaria and Anti?Erythrocyte Autoimmunity (pages 137–158): W. Jarra
Chapter 10 Genetic version within the Host and Adaptive Phenomena in Plasmodium falciparum an infection (pages 159–173): L. Luzzatto, F, O. Sodeinde and G. Martinit
Chapter eleven Glycophorins and purple cellphone Invasion by way of Plasmodium falciparum (pages 174–195): Geoffrey Pasvol and Michele Jungery
Chapter 12 Expression of Inherited Resistance to Malaria in tradition (pages 196–205): Milton J. Friedman
Chapter thirteen Metabolism and floor shipping of Parasitized Erythrocytes in Malaria (pages 206–221): Irwin W. Sherman
Chapter 14 Mode of motion of Antimalarial medicinal drugs (pages 221–245): Coy D. Fitch
Chapter 15 final comments (pages 246–247): D.J. Weatherall

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Extra resources for Ciba Foundation Symposium 94 - Malaria and the Red Cell

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Malariae gametocytes do have excrescences and therefore presumably synthesize the protein. As indicated previously, the specificity of the exposed portion of the histidine-rich protein is also a matter of extreme interest. Although rabbit anti-P. lophurae histidine-rich protein serum cross-reacts at low titre (Kilejian 1980b), it is difficult to escape the conclusion that in normal circumstances the histidine-rich protein is poorly immunogenic or is phenotypically variable. If not, parasitized erythrocytes would be readily removed from the circulation and infection rapidly terminated.

Practically all studies of antigens have been confined to the asexual parasites, while ultrastructural observations indicate that gametocytes will differ antigenically in many respects from asexual forms, both in the presence of type-specific antigens, and in the sequence in which similar antigens are synthesized. Parasite maturation also results in the appearance of new structures in the erythrocyte cytoplasm and in changes in the erythrocyte membrane. Parasitederived antigens appear in the membrane, and the erythrocyte membrane may itself become isoantigenic.

Falciparurn (Perrin & Dayal 1982), P. chabaudi and P . berghei (Newbold et a1 1982b), and by immunofluorescence and agglutination on the surface of merozoites of P. yoelii (Holder & Freeman 1982), P. knowlesi (Epstein et a1 1981) and P. chabaudi (D. B. Boyle, personal communication). The 235K protein of P. yoelii has been tentatively localized in the internal organs of the merozoite. From the ultrastructural evidence and the timing of their differentiation, two distinct secretory organelles, the rhoptries and micronemes, appear to be particularly concerned with the escape of merozoites from the erythrocyte and their entry into fresh cells.

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