By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins(auth.)
Chapter 1 the traditional Bone Marrow (pages 1–50):
Chapter 2 targeted concepts acceptable to Bone Marrow prognosis (pages 51–89):
Chapter three an infection and Reactive adjustments (pages 90–140):
Chapter four Acute Myeloid Leukaemia, the Myelodysplastic Syndromes and Histiocytic Neoplasms (pages 141–190):
Chapter five persistent Myeloproliferative and Myeloproliferative/Myelodysplastic problems (pages 191–230):
Chapter 6 Lymphoproliferative issues (pages 231–331):
Chapter 7 a number of Myeloma and similar issues (pages 332–359):
Chapter eight problems of Erythropoiesis, Granulopoiesis and Thrombopoiesis (pages 360–390):
Chapter nine Miscellaneous issues (pages 391–429):
Chapter 10 Metastatic Tumours (pages 430–461):
Chapter eleven ailments of Bone (pages 462–473):
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Content material: bankruptcy 1 the traditional Bone Marrow (pages 1–50): bankruptcy 2 detailed thoughts acceptable to Bone Marrow analysis (pages 51–89): bankruptcy three an infection and Reactive adjustments (pages 90–140): bankruptcy four Acute Myeloid Leukaemia, the Myelodysplastic Syndromes and Histiocytic Neoplasms (pages 141–190): bankruptcy five power Myeloproliferative and Myeloproliferative/Myelodysplastic problems (pages 191–230): bankruptcy 6 Lymphoproliferative issues (pages 231–331): bankruptcy 7 a number of Myeloma and similar issues (pages 332–359): bankruptcy eight issues of Erythropoiesis, Granulopoiesis and Thrombopoiesis (pages 360–390): bankruptcy nine Miscellaneous issues (pages 391–429): bankruptcy 10 Metastatic Tumours (pages 430–461): bankruptcy eleven illnesses of Bone (pages 462–473):
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Additional resources for Bone Marrow Pathology, Third Edition
B) Section of BM showing a bone spicule; one side is lined with osteoblasts while the other shows Howship’s lacunae, two of which contain osteoclasts. H&E ×376. (b) Histology In sections of bone marrow, the fat cells appear in clusters, separated by haemopoietic tissue. They are often particularly prominent adjacent to trabeculae. Fat cells appear as empty spaces with an oval nucleus at one edge of the cell. with myeloid cells, all of these lineages being derived from a pluripotent stem cell. The bone marrow contains mature cells and precursor cells of both T- and B-lymphoid lineages.
Artefacts Various artefacts in bone marrow aspirates and trephine biopsies need to be recognized so that they are not misinterpreted as evidence of disease. Artefacts are of three main types: (i) introduced by the biopsy process or by processing in the laboratory; (ii) consequent on extraneous material or tissue being included in the biopsy; and (iii) consequent on previous tissue damage at the biopsy site. The latter group are not, strictly speaking, artefacts since what is observed are real changes in the tissues.
Lymphoid follicles are discussed further on page 114. Plasma cells Cytology Plasma cells (Fig. 48) are infrequent in normal bone marrow in which they rarely constitute more than 1% of nucleated cells. In healthy children they are even less frequent . They are distinctive cells with a diameter of 15–20 µm and an eccentric nucleus, moderately basophilic cytoplasm and a prominent paranuclear Golgi zone. The cytoplasm may contain occasional vacuoles and sometimes stains pink with a May–Grünwald–Giemsa (MGG) stain, consequent on the presence of carbohydrate.