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Extra info for Bipolar Disorder - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Generate_Screen Studies 37 • Project Title: TRANSCRANIAL MAGNETIC STIMULATION IN BIPOLAR DISORDER Principal Investigator & Institution: Pascual-Leone, Alvaro; Associate Professor; Beth Israel Deaconess Medical Center E/Es-214 Boston, Ma 02215 Timing: Fiscal Year 2001 Summary: This abstract is not available.
The following biological markers will be examined as measures of compliance with the study protocol and/or as possible predictors of response to 03FA: 1. Plasma and erythrocyte fatty acid content. 2. The niacin skin patch test (a possible marker of in vivo omega-3 fatty acid activity). 3. Preliminary development of methods to noninvasively measure the 03FA content in brain using C13 magnetic resonance spectroscopy. If 03FA are indeed effective mood stabilizers for bipolar disorder, this project would provide additional evidence of aberrant signal transduction mechanisms in the pathophysiology of bipolar disorder, and may herald the advent of a new class of rationally designed mood stabilizing drugs.
Of the Genetics and Neurodevelopmental Core of the Mental Health Clinical Research Center on Regional Brain Function in Schizophrenia at the University of Pennsylvania. The two studies proposed in this application attempt to begin to test a neurodevelopmental model for BP. The first study takes an epidemiologic approach and examines the contributions of prospectively-assessed prenatal and 32 Bipolar Disorder perinatal complications and indices of neuropsychological deviance during early childhood to the prediction of adult BP I disorder in a birth cohort studied as part of the National Collaborative Perinatal Project (NCPP).