Bioorganic Chemistry: A Chemical Approach to Enzyme Action by Hermann Dugas

By Hermann Dugas

This widely-praised textbook is especially fitted to complex undergraduates or graduates in chemistry, biochemistry, medicinal chemistry, and pharmacology. The 3rd version has been considerably revised to mirror new examine within the box, and lines an incredible new bankruptcy on self-assembly, auto-organization, and molecular units. the phenomenal figures stay a spotlight of the booklet, and have been defined in an prior variation as "the most sensible i have obvious for displaying the natural chemistry of biomolecules." (Quart. Rev. Biol.)

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571) R ~HEB Aldolases in saccharides, nature's major way to make C-C bonds cO -----,>- 0 II HNAN>(oe R-C-R' II o Decarboxylation of ~-activated acids, Krebs cycle (p. 25) Biotin carboxylation (or dicarboxylation) dependent enzyme, "activated C02" (p. 1 (continued) Aldol condensation, retro aldol, formation and cleavage of C--C bonds Reductive decarboxylation of a-keto acids, benzoin condensation Decarboxylation of ~-keto and ~-hydroxy acids, cleavage of a C-C bond Addition of C02, formation of a C--C bond, DCC-like intermediate Bayer-Villiger reaction, oxygen insertion VJ '" ~ ~.

In turn, each aminoacyltRNA synthetase enzyme will accept only its particular amino acid as a substrate. However, it has been possible to slightly modify the naturally occurring amino acids and have them serve as substrates for the enzyme. For example, p-fluorophenylalanine can substitute to some extent for phenylalanine. 3 Chemistry of the Peptide Bond R-CH / Cooe ""'NH 3 $ 39 + ATP + tRNA(3'-OH) amino acid -pp I ll Mg 2 • amlnoacyl-tRNA synthetase intermediate anhydride /OH tRNA ll-AMP o H3 R"", II CH-C-O-tRNA N/ aminoacyl-tRNA Once synthesis of the aminoacyl-tRNA is complete, the amino acid no longer serves a recognition function.

G o· IJj '" S p.. o·~ ~ S o· 0> ~ =s 0 ad 0> ... o ~ ~ N N R' (p. 186) 0 .. _) Thiamine-pyrophosphate-dependent decarboxylase, "biological cyanide ion" (p. 571) R ~HEB Aldolases in saccharides, nature's major way to make C-C bonds cO -----,>- 0 II HNAN>(oe R-C-R' II o Decarboxylation of ~-activated acids, Krebs cycle (p. 25) Biotin carboxylation (or dicarboxylation) dependent enzyme, "activated C02" (p. 1 (continued) Aldol condensation, retro aldol, formation and cleavage of C--C bonds Reductive decarboxylation of a-keto acids, benzoin condensation Decarboxylation of ~-keto and ~-hydroxy acids, cleavage of a C-C bond Addition of C02, formation of a C--C bond, DCC-like intermediate Bayer-Villiger reaction, oxygen insertion VJ '" ~ ~.

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