ATP and the Heart by Joanne S. Ingwall Ph.D. (auth.)

By Joanne S. Ingwall Ph.D. (auth.)

ATP performs a significant function within the top reasons of cardiac morbidity and mortality within the western international: ischemia and middle failure. we're in our infancy employing what's identified approximately biology and chemistry of ATP towards constructing powerful remedies for those ailments. during this quantity, the present figuring out of the chemistry and biology of ATP particularly within the cardiomyocyte is gifted. New insights into ATP were gleaned utilizing biophysical recommendations permitting dynamic size of chemical occasions within the intact beating middle and utilizing new animal types during which cardiac proteins are both over expressed, deleted or harbor particular mutations.

This booklet offers a precis of the fundamental realizing and contains illustrations of why ATP and the Heart is necessary to either the clinician and scientist.

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3. Polimeni PI. Measurement of myocardial electrolyte distribution. Tech Life Sci Cardiovasc Physiol. 1984;317: 1-34. 4. Lowry OH, Rosenbrough NJ, FaIT AL, Randall RJ. Protein measurement with the folin phenol reagent. J Bioi Chem. 1951; 193 :H729-H744. 5. Anversa P, Beghi C, Kikkawa Y, Olivetti G. Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth. Circ Res. 1986;58:26-37. 6. Gadian DG. NMR and its application to living systems. 2 ed. ; 1995. 7. Ingwall JS. Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles.

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