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The publication provides a complete evaluation of the present state of the art within the atmospheric boundary layer (ABL) learn. It makes a speciality of experimental ABL study, whereas many of the books on ABL talk about it from a theoretical or fluid dynamics perspective. Experimental ABL learn has been made up to now by way of surface-based in-situ experimentation (tower measurements as much as a number of hundred meters, floor strength stability measurements, brief plane experiments, brief experiments with tethered balloons, constant-level balloons, overview of radiosonde data).
This can be a 3-in-1 reference ebook. It supplies a whole scientific dictionary protecting thousands of phrases and expressions in relation to ear infections. It additionally offers vast lists of bibliographic citations. ultimately, it offers details to clients on tips on how to replace their wisdom utilizing a variety of web assets.
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3. To characterize the specific effects of CD8+ T cell recognition in the absence of IFN-gamma on antigen-presenting epithelial cells and the impact on progression to chronic pulmonary inflammation. ; Medicine; Duke University Durham, Nc 27706 Timing: Fiscal Year 2002; Project Start 21-SEP-2001; Project End 31-AUG-2004 Summary: (adapted from the application) Current treatment options for chronic hepatitis C infection remain limited and unsatisfactory. Treatment with interferon-alpha and ribavirin leads to a sustained response in the minority of patients, and many patients may not be eligible for treatment due to side effects associated with these medications.
Together, we now propose to identify and characterize MTB genes that control the formation of pulmonary cavities. We will use: 1) two different DNA microarrays to determine, on a genome wide scale, the presence and expression profile of all MTB genes; 2) a new mouse model that manifests the type of caseating granuloma that gives rise to cavities; and 3) conventional genetic approaches for gene knock-outs and complementation. We will build a matrix database of well characterized clinical isolates that records clinical cavity formation, results of assays of toxic lipids and whole genome DNA microarray identification of gene deletion and expression.
The principal investigator recently demonstrated that intratracheal (IT) injection of manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) protects the murine lung from irradiation-induced organizing alveolitis/fibrosis induced by single dose or fractionated irradiation. The proposed research will use validated, genetically modified animal models along with quantitative molecular methods to elucidate the cellular mechanism of irradiation lung fibrosis and the level(s) at which epitope-hemagglutinin (HA)-tagged MnSOD transgene therapy protects.